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Adju-Phos® Literature

Recommended reading about aluminum phosphate ADJUVANTS:

Burrell, L.S.; Lindblad, E.B.; White, J.L. and Hem, S.L. (1999).
Stability of Aluminum-Containing ADJUVANTS to Autoclaving.
VACCINE 17: 2599-2603.

Hem, S.L., Klepak, P. and Lindblad, E.B. (2004) + (2005). Monograph: Aluminum Phosphate ADJUVANT in: Handbook of Pharmaceutical Excipients. Pharmaceutical Press Ltd., London.

Lindblad, E.B. (2004)
Aluminum ADJUVANTS–in Retrospect and Prospect.
VACCINE 22 (27-28) 3658-3668.

Lindblad, E.B. (2004)
Aluminum Compounds for Use in Vaccines Immunol.
Cell Biol. 82 (5) 497-505.

Lindblad, E.B. (2006)
Are mineral ADJUVANTS triggering TLR2/TLR4 on dendritic cells by a secondary cascade reaction in vivo through the action of heat shock proteins and danger signals? (Editorial Letter).
VACCINE 24 : 697-698.

Leenaars, P.P.A.M.; Hendriksen, C.F.M.; de Leeuw, W.A.; Carat, F.; Delahaut, P.; Fischer, R.; Halder, M.; Hanley, W.C.; Hartinger, J.; Hau, J.; Lindblad, E.B.; Nicklas, W.; Outschoorn, I.M. and Stewart-Tull, D.E.S. (1999).
The Production of Polyclonal Antibodies in Laboratory Animals.
The Report and Recommendations of ECVAM/FELASA Workshop 35.

ATLA 27: 70-102.

Shirodkar, S.; Hutchinson, R.L.; Perry, D.L.; White, J.L. and Hem, S.L.
Aluminum Compounds Used as ADJUVANTS in Vaccines.
Pharm. Res. 1990, 7 (12), 1282-1288.

Johnston, C.F.; Wang, S-L. and Hem, S.L.
Measuring the surface area of aluminum hydroxide ADJUVANT.
J. Pharm. Sci.2002, 91 (7) 1702-1706.

Seeber, S.J.; White, J.L. and Hem, S.L.
Predicting the adsorption of proteins by aluminum-containing ADJUVANTS.
Vaccine 1991, 9, 201-203.

Lindblad, E.B. (2007)
Safety Evaluation of Vaccine ADJUVANTS.
Chapter 18 in: Vaccine ADJUVANTS and Delivery Systems.
Ed. M. Singh : p 421-444.
John Wiley & Sons Publishers.

Mannhalter, J. W.; Neychev, H.O.; Zlabinger, G.J.; Ahmad, R. and Eibl, M.M.
Modulation of the human immune response by the non-toxic and non-pyrogenic ADJUVANT aluminum hydroxide: Effect on antigen uptake and antigen presentation.
Clin. Exp. Immunol. 1985, 61 (1), 143-151.

Iyer, S.; HogenEsch, H. and Hem, S.L.
Effect of the degree of phosphate substitution in aluminum hydroxide ADJUVANT on the adsorption of phosphorylated proteins.
Pharm. Dev. Tech.2003, 8, 81-86.

Vassilev, T.L.
Aluminum phosphate but not calcium phosphate stimulates the specific IgEresponse in guinea pigs to tetanus toxoid.
Allergy 1978 33: 155-159.

Davenport, F.M.; Hennessy, A.V. and Askin, F.B.
Lack of ADJUVANT Effect of AlPO4on Purified Influenza Virus Hemagglutininsin Man.
J. Immunol. 1968, 100 (5), 1139-1140.

Kwissa, M.; Lindblad, E.B.; Schirmbeck, R. and Reimann, J. (2003)
Co-delivery of a DNA Vaccine and a Protein Vaccine with Aluminum Phosphate Stimulates a Potent and Multivalent Immune Response.
J. Mol. Med. 81:8. 502-511.

Jankovic, D.; Caspar, P.; Zweig, M.; Garcia-Moll, M.; Showalter, S.D.; Vogel, F.R. and Sher, A.
Adsorption to aluminum hydroxide promotes the activity of IL-12 as an ADJUVANT for antibody as well as type 1 cytokine responses to HIV-1 gp120.
J. Immunol. 1999, 163: 4481-4488.

Rimaniol, A-C.; Gras, G.; Verdier, F.; Capel, F.; Grigoriev, V.B.; Porcheray, F.; Sauzeat, E.; Fournier, J.-G.; Clayette, P.; Siegrist, C.-A. and Dormont. D.
Aluminum hydroxide ADJUVANT induces macrophage differentiation towards a specialized antigen-presenting cell type.
Vaccine 2004 22: 3127-3135.

Shi, Y.; HogenEsch, H.; Regnier, F.E. and Hem, S.L.
Detoxification of endotoxin by aluminum hydroxide ADJUVANT.
Vaccine 2001, 19 :1747-1752